![]() The combined data of 16 RCTs revealed that CoQ10 significantly reduced circulating CRP among individuals over 50 years old. Subgroup analyses demonstrated significant reduction of circulating CRP in individuals who received 100-200 mg daily and the maximum effect observed at 300-400 mg daily. Pooled estimates found that CoQ10 significantly reduced circulating CRP levels. Over 20 studies including a total of 1,145 participants measured circulating CRP after CoQ10 supplementation. Tumor necrosis factor alpha (TNF-alpha) is produced mainly by macrophages and contributes to production of interleukin-6 (IL-6), as well as C-reactive protein (CRP), which directs the chronic inflammatory process in the body. The meta-analysis looked at studies that used three common inflammatory markers frequently used in studies of aging: TNF-alpha, IL-6 and CRP. The daily dose of CoQ10 varied from 30mg to 500mg and the duration ranged from two to 48 weeks. Participants were divided into six categories according to health status, distinguishing between healthy subjects and those with cardiovascular disease (CVD) and other diseases. The range of mean age among these participants was 17 to 79 years with most of the studies including both males and females. In total, these trials involved over 1,500 participants, with 766 assigned to the CoQ10 group and 751 assigned to the control group. ![]() ![]() Of the 6,713 studies identified through the initial database search, 31 studies met the inclusion criteria and were included in the meta-analysis. The endogenous production of CoQ10 decreases after the age of 20, and myocardial concentration of CoQ10 is reduced to about half by the age of 80, according to a 2019 study.Ī systematic literature search of PubMed, Embase and Cochrane Library electronic databases was conducted for RCTs concerning the effects of CoQ10 supplementation on outcomes of common inflammatory markers between 20. As one of the most powerful lipid antioxidants, CoQ10 can counteract reactive oxygen species (ROS) reactions, recover other antioxidants, and prevent membranes and cells from lipid peroxidation, avoiding cell damage and cell death.ĬoQ10 deficiency can result from genetic inborn errors, certain medications, and aging. These findings were published in the journal Molecular Nutrition & Food Research.Ĭoenzyme Q10 (CoQ10), also known as ubiquinone, is an endogenous lipophilic compound involved in many critical cellular pathways. With previous meta-analyses demonstrating mixed effects of Coenzyme Q10 (CoQ10) on inflammatory markers, researchers from China sought to assess the efficacy and optimal dose of CoQ10 supplementation on inflammatory markers in the general population.Īccording to the authors, this was the first study to assess the daily optimal and safe dose of CoQ10 supplementation needed to achieve anti-inflammatory effects. China: Probiotic supplements in e-commerce.Digestion and immunity probiotic supplements in e-commerce.Explained: The US e-commerce probiotic supplements market.Probiotic supplements: Global e-commerce 2018-2020, forecast for 2021.The gut-brain axis: Psychobiotic opportunity in 25 countries.
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